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Author (up) Passen, E.L.; Andersen, B.R. url  openurl
  Title Clinical tetanus despite a protective level of toxin-neutralizing antibody Type Journal Article
  Year 1986 Publication JAMA : the Journal of the American Medical Association Abbreviated Journal Jama  
  Volume 255 Issue 9 Pages 1171-1173  
  Keywords Adult; Antibodies, Bacterial/*analysis; Foot Injuries; Humans; Immunization, Passive; Male; Neutralization Tests; Tetanus/etiology/*immunology/therapy; Tetanus Antitoxin/analysis; Tetanus Toxin/*immunology; Tetanus Toxoid/administration & dosage; Wounds, Penetrating/complications  
  Abstract TETANUS is a preventable disease. Although immunization guidelines are generally very effective, tetanus has occurred in patients with prior immunization. In most cases it was presumed that levels of toxin-neutralizing antibody were low. Although data on the protective level of neutralizing antibody in humans are extremely limited, animal data have been used to support the belief that 0.01 antitoxin unit/mL is protective. This report describes a patient with a wound, followed by severe generalized tetanus, who was found at the onset of symptoms to have a neutralizing antibody level 16 times that considered protective.

Report of a Case

A 35-year-old man sustained a puncture wound in the plantar surface of his left foot. He was seen at a community hospital 35 hours later for increasing foot pain. There was no evidence of infection, and he was treated with tetanus toxoid, dicloxacillin, and acetaminophen.
 
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0098-7484 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2868135 Approved no  
  Call Number DP @ pierredeterre2007 @ Serial 498  
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