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Author (up) Miravalle, A.; Roos, K.L. url  doi
openurl 
  Title Encephalitis complicating smallpox vaccination Type Journal Article
  Year 2003 Publication Archives of Neurology Abbreviated Journal Arch Neurol  
  Volume 60 Issue 7 Pages 925-928  
  Keywords Animals; Encephalomyelitis, Acute Disseminated/diagnosis/*epidemiology/*etiology/physiopathology/therapy; Humans; Incidence; Smallpox Vaccine/*adverse effects/immunology  
  Abstract A smallpox vaccination program has been initiated. The vaccine is a live virus that was used in the last century. Postvaccinal encephalitis is a complication of this vaccine. The clinical presentation, course, neuroimaging findings, and spinal fluid abnormalities are similar to a disorder that physicians are familiar with, acute disseminated encephalomyelitis. This complication can be prevented with the administration of antivaccinia gamma globulin at the time of vaccination. Antivaccinia gamma globulin is not efficacious once this complication occurs. Intravenous methylprednisolone is the recommended therapy, although intravenous immunoglobulin and plasmapheresis should be investigated in the treatment of postvaccinal encephalitis.  
  Address Department of Neurology, Indiana University School of Medicine, and Indiana University Hospital, Indianapolis, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0003-9942 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12873847 Approved no  
  Call Number DP @ pierredeterre2007 @ Serial 28  
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